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This reduction in inhibitory tone enhances the stimulatory effects of GHRH, allowing greater somatotroph responsiveness
doi: 10.1186/s12933-017-0646-z 22 LiuXHuangJLiJMaoQHeJ
That modification is the key engineering trick: it makes the molecule more resistant to the enzymes that would normally break GHRH down quickly, giving tesamorelin a longer working window than sermorelin while still acting on the same GHRH receptor
Knasmuller et al
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