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www.ema.europa.eu (18 2022)
The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly degrades circulating GLP-1, which is why pharmaceutical versions are chemically modified to resist this breakdown and maintain therapeutic levels for extended periods
Furthermore, earlier evaluations by NICE and HAS did not incorporate retreatment in their economic models, 26,27 and the Japanese HTA largely followed these international approaches
More research is certainly needed on this topic
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