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Around 30% of inactive WT or V229A receptors existed as dimers to hexamers or hexamers to decamers, with a tendency for the dimer to hexamer population to reduce and the hexamer to decamer population to increase after exendin-4 stimulation, and for GLP-1R V229A to have a higher proportion of hexamers to decamers under vehicle conditions versus WT receptors
Because of its very short half-life, native GLP-1 cannot be used for therapeutic purposes
Similar peptides BPC-157 occupies a unique position within the regenerative research peptide class
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