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WARNING Before using metformin, tell your health care provider about your medical history, especially if you have: kidney disease heart disease or congestive heart failure liver disease metabolic acidosis or diabetic ketoacidosis high ketone levels in your blood or urine you use insulin or other diabetes medications Talk to your health care provider if you are planning to become pregnant or if pregnant or breastfeeding

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Besides biological explanations, social factors like better adherence or a stronger motivation to lose weight among women might explain some of the differences

Tesamorelin alone produces consistent GH elevation