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It's whether the evidence of benefit outweighs the evidence of harm at a population scale, across diverse patients, over meaningful time horizons
They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)
10.1038/nrclinonc.2015.121 Nat
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