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A potent compound in a dish may fail to cross the bloodbrain barrier, be metabolically inactivated systemically, or elicit unexpected off-target effects within the integrated neurovascular unit, where a drugs action on one cell type can inadvertently impact another, as exemplified by the context-dependent role of molecules like GLRX5 (Zhou S., 2024

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doctors and genetic counselors can advise you on the decision to have this type of test