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Quick Answer: Semaglutide is not contraindicated in Crohn's disease, but requires individualized assessment based on disease activity, nutritional status, and gastrointestinal symptom tolerance

In systemic circulation, only about 12% of liraglutide exists in the unbound (free) form, while the remainder is reversibly bound to albumin, effectively serving as a depot that enables sustained pharmacological action

In that case, sterile water for injection (SWI) is the alternative but you'd need to reconstitute fresh for each dose or within 24 hours