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Current FDA-approved treatments, such as disulfiram, acamprosate and naltrexone, can help manage AUD by reducing consumption and relapse risk, but their effectiveness varies widely across individuals (Heilig et al
In a phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest doses of retatrutide achieved a mean weight reduction of approximately 1724% of body weight over 48 weeks, depending on dose
Among these patients, 39% of weight lost was lean mass, not fat
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