2022, pp
If a patient comes to me wanting to lose 40 pounds, I'm not handing them AOD-9604 and a multivitamin
preconception weight loss and glycemic control lower maternal-fetal risk Monitoring Plan: Data-Driven Adjustments We track: Anthropometrics : weight, waist, body composition Glycemic measures : fasting glucose, A1C, insulin, CGM phenotyping Lipids/liver enzymes : MASLD risk and cardiometabolic trends Hormonal markers : SHBG/androgens as indicated Behavioral health : binge frequency, sleep, stress Physical function : strength/mobility/tolerance/pain Autonomic indicators : HRV where available Decision Points for Plan Adjustments Binges persist beyond 812 weeks: add lisdexamfetamine with screening GI intolerance limits metformin: extend titration, adjust timing, consider alternatives Weight loss plateaus: review meal composition, protein adequacy, micro-bouts, sleep, medication dosing Mood/sleep deteriorate: adjust stimulant use, exercise timing, prioritize autonomic interventions Labs stall: reassess adherence, doses, alcohol intake, comorbidities Long-Term Maintenance: Anti-Relapse Ecosystem Minimal effective pharmacology : maintain doses that uphold stability Protect lean mass : never abandon resistance training Sustain meal rhythm : protein-fiber anchors and evening scripts Seasonal planning : holiday/travel stress playbooks Regular touchpoints : quarterly check-ins, annual labs, chiropractic/rehab tune-ups Case Journey 2: George Male Metabolic Health, Hypertension, Prediabetes, Fertility Concerns, Mood and Stress I introduce George, a 35-year-old nonsmoker, high-pressure tech project manager, facing fertility challenges (low sperm count) and significant stress, anxiety, occasional erectile dysfunction, elevated blood pressure, and visceral adiposity
Plitman E, de la Fuente-Sandoval C, Reyes-Madrigal F, Chavez S, Gmez-Cruz G, Len-Ortiz P, et al
