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It is upregulated in response to tissue injury, hypoxia, metabolic stress, and inflammation acting as a damage-sensing and repair-initiating signalling complex
For many vitamins, this oral route is perfectly effective
Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates
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