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FIGURE 2 The primary ROS produced by the ETC is superoxide, a free radical with moderate reactivity, whose generation can lead to more reactive or secondary ROS derivatives

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Lipid-drug conjugates (LDCs) represent a new class of compounds generated through the lipophilic modification of water-soluble or poorly soluble drugs

Nevertheless, since GSH cannot be administered directlybecause of its insufficient absorption, stability and solubilityanalogues have been obtained, through modifications at the -glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105