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SUMOylation is a small ubiquitin-like modifier (SUMO) connected to the substrate protein through a tertiary enzymatic reaction ( 2 O 2 group in the phospholipid fatty acid chain, resulting in the inhibition of lipid peroxidation of the cell membrane in silico ( Since GPX4 is a core regulator of ferroptosis, although it is unknown whether the phosphorylation, glycosylation or SUMOylation of GPX4 affect ferroptosis, it would be of interest to investigate it in future translational studies
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