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This stability allows researchers to investigate both oral and parenteral administration routes in animal-model designs, an unusual flexibility among peptide research compounds
Neuropharmacology 46 , 404411 (2004)
Additionally, Candida albicans secretes aspartyl proteinases (SAPs) that degrade mitochondrial structural and metabolic proteins, further impairing mitochondrial integrity and energy production ( Cryptococcus neoformans utilizes a polysaccharide capsule to suppress mitochondrial metabolism in macrophages, decreasing mtROS production and blunting fungicidal activity ( 4.2 Fungal-mediated disruption of mitochondrial bioenergetics and ETC function Mitochondrial OXPHOS serves as a key energy source for immune cell function, particularly for macrophages and dendritic cells engaged in antifungal defense
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