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The binding of IL-6 to receptors on precursor osteoclasts stimulates osteoclast formation, leading to elevated bone resorption (Harmer et al
The article points out that with an extended-duration injectable, the medication remains in the system for weeks after the last dose, so intolerable side effects require patience while levels fall
Balkan J, et al
People with a previous history of kidney stones may need closer monitoring
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