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Clinical and animal studies have demonstrated the efficacy of benfotiamine in the treatment of diabetes-related neuropathy, kidney disease, peripheral vascular disease, and retinopathy (Stirban 2006
PMID: 14584018 National Institute of Mental Health [Internet] Bethesda, MD
This enhances the expression and activity of NRF2, resulting in significantly reduced ROS levels in lipopolysaccharide (LPS)-activated microglial cells [147]
Additional warnings include risk of pancreatitis, gallbladder disease, acute kidney injury, hypersensitivity reactions, and caution in patients with severe gastrointestinal disease including gastroparesis
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