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However, a pilot randomized controlled trial (RCT) of pioglitazone in patients with poorly controlled asthma with comorbid obesity was prematurely discontinued due to new safety concerns around the risk for bladder cancer [77]
Technically, scope is defined by competency, not diagnosis
There are medical guidelines for the treatment of obesity, and this often involves adjusting a plan as circumstances change
Applying a clinically meaningful number or difference helps to prevent trials from being declared positive based solely on statistical significance
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