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Similarly, disruption in SQLE gene expression has been associated with changes in taxa related to cholesterol metabolism and intestinal barrier integrity, including Desulfovibrio fairfieldensis and members of Lachnospiraceae ( PTLP , rs9363741 in AL365503.1 , rs148330122 in SIPA1L3 , and rs3010562 in TTLL2 , have been linked to changes in bacterial groups such as Erysipelotrichaceae, Lachnobacterium, Bacilli , and Anaerofilum ( These findings suggest that host genetics may influence microbiota composition and function through pathways related to lipid metabolism, bile acid signaling, immune tone, and intestinal barrier regulation

The mechanism by which GLP-1 receptor agonists work primarily involves enhancing glucose-dependent insulin secretion, suppressing glucagon release, and slowing gastric emptying

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Figure 1 and Table S2 report full cAMP agonism with receptor-specific potency differences