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The company is evaluating single-agent and combination therapy approaches against the core pathways associated with NASH hepatocyte lipotoxicity, inflammation and fibrosis

As an oral medication, it might be more appealing to those wary of injections

Parts A, B, and C of the study are looking at several other research questions, including: What side effects may happen from taking the study drug How much study drug is in the blood at different times Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) Full description Part A Healthy Volunteers Part B and Part C (starts after treatment for Part A has completed) Participants with Obesity Volunteers Accepts Healthy Volunteers Inclusion and exclusion criteria Key Inclusion Criteria Part A Male or female participants age 18 to 55 years of age at the time of screening BMI 18 and 32 kg/m2, at the screening visit Part B and Part C Male or female participants 18 to 80 years of age at the time of screening BMI 30 kg/m2, at the screening visit History of 1 or more self-reported unsuccessful dietary attempts to lose weight Key Exclusion Criteria History of diabetes (Type 2 or Type 1)

While its exact mechanism is still being studied, we know it works primarily in the central nervous system