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Lower (but not excessively low) IGF-1 activity is linked to longevity, but excessively high IGF-1 can fuel abnormal cell growth, suppress apoptosis (the natural death of damaged cells), and drive the development of cancer
Starting at a low dose and increasing gradually which Found's titration protocol is designed to do helps reduce their intensity
In 2017, another clinical study showed that melatonin intake (10 mg/day, P.O for 12 weeks) increased serum GSH levels while reducing serum MDA and protein carbonyl (PCO) in CHD patients with type 2 diabetes
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