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It is designed to be taken once daily alongside a reduced-calorie diet and increased physical activity
NICE NG28 recommends prioritising SGLT-2 inhibitors in people with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease often alongside or instead of metformin due to these organ-protective effects [10] [8] GLP-1 receptor agonists (e.g., semaglutide, liraglutide) generally produce greater HbA1c reductions (1.01.5%) and significant weight loss, but are injectable and more costly
De La Torre screens for these during the initial visit
By contrast, NAT2 is not evident until about 12 months after birth (ParienteKhayat et al., 1991)
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