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The irony of this is that in the very same guidelines they recommended holding one dose of GLP-1 RAs prior to surgery despite having no evidence that this would minimize residual gastric contents

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However, independent lines of evidence continue to support involvement of FNDC5/irisin signaling in metabolic adaptation, bone remodeling, and neuroprotection, suggesting that early technical limitations may have obscured rather than invalidated its physiological relevance ( A key limitation for irisin translation remains the absence of a definitively identified receptor