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Research using MC4R knockout mice and selective MC4R antagonists has established MC4R as the primary receptor mediating MT-IIs pro-erectile and pro-sexual effects with MC4R-null mice showing substantially reduced or absent MT-II-induced erections and sexual behaviour, and MC4R-selective antagonists blocking these responses at doses not affecting MT-IIs melanogenic activity

doi: 10.1096/fj.202002200R 241 WalkerJLZhaiNZhangLBleakenBMWolffIGerhartJet al

Open communication about health status and medication history is essential

Chronic inflammation from any source, whether autoimmune, metabolic, or infectious, competes with and often overwhelms the anti-inflammatory effects of neuroprotective peptides