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While magnesium may influence insulin sensitivity, supplementation should be based on deficiency rather than for diabetes management

Dietary modifications significantly impact tolerability: Consume smaller, more frequent meals rather than large portions Avoid high-fat, spicy, or heavily processed foods that may exacerbate nausea Maintain adequate hydration (1.52 litres daily for most people, though this may need adjustment for those with heart or kidney conditions) Increase dietary fibre gradually to support regular bowel movements Eat slowly and chew thoroughly, as gastric emptying is delayed Physical activity and postural support help address musculoskeletal symptoms: Engage in regular, moderate exercise including core-strengthening activities Consider physiotherapy assessment if back pain persists Maintain good posture and ergonomic practices, particularly during sedentary activities Use appropriate footwear and consider orthotics if biomechanical changes are significant Incorporate stretching and flexibility exercises into daily routines Pharmacological adjuncts may be appropriate for specific symptoms

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3 In vitro distribution model At present, the drugplasma protein binding model and bloodbrain barrier model have been well studied in vitro