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Overall, the available data indicate that ferroptosis sensitivity is governed not only by antioxidant abundance but by their spatial deployment, upstream metabolic wiring and delivery modality, with the CoQFSP1mevalonate axis providing multiple experimentally validated nodes for both smallmolecule and ADCbased therapies
Because DSIP has also been discussed in some studies in connection with the internal clock and thermoregulation, the two overlap thematically in the field of chronobiological research
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Lower platelet counts, attributed to cancer diagnosis and treatment, may also contribute to lower BDNF levels as a large percentage of circulating BDNF is stored in platelets 25
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