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Use of OAs have evolved from investigating IEM to providing insight into functional metabolic imbalances
When PIO was added on top of an SGLT2 inhibitor in patients with T2D and NAFLD it promoted significant improvements of liver function tests, as well as non-invasive quantitative biomarkers that estimate liver steatosis and fibrosis
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The main objective is to suppress menses, thus inducing iatrogenic menopause or pseudopregnancy, which in turn reduces pain symptoms in order to prevent or postpone surgery, which is useful for long-term management of the disease
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