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Deamidation Asparagine and glutamine residues in peptides can undergo deamidation, a reaction where the amide group is replaced by a carboxyl group
This stress, which damages hepatocytes, also induces transcription and secretion of FGF21, which appears able to act directly on hepatocytes as a paracrine or autocrine hormone (59, 60)
Cagrilintide on its own may still be useful, especially for people who cannot take GLP-1 drugs or as part of a mix of treatments
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