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[17] Hasbi H, Sonjaya H, Gustina S

In contrast, other meta-analyses have found no significant change in HDL levels in response to IF [23, 32]

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

Understanding why researchers pursued this neurotrophic compound for AD, what preclinical evidence showed, and why the clinical translation ultimately failed provides crucial context for anyone evaluating Dihexa's potential