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A significant portion of Americans have embraced freedom of therapeutic choice as a constitutional value for most of the countrys history, Lewis Grossman, a medical historian, writes in his book Choose Your Medicine. Benjamin Rush, a Founding Father and a physician, criticized the medical establishment for being closed-minded about treatments recommended by non-physicians

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Although methylcobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product (see Hydroxocobalamin monograph), and methylcobalamin