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Medications such as antimicrobials, phenytoin, proton-pump inhibitors, allopurinol, lithium, and antivirals have been implicated in this condition (Rossert 2001)
52 Cellular stress, such as DNA damage, hypoxia, and oncogene activation, disturbs the interaction between p53 and MDM2 and inhibits p53 degradation, resulting in p53 accumulation
The increase in potential exposure in recent years is apparent from our study, in which, among a broader cohort of more than 2.1 million pregnancies, the prevalence of GLP-1 dispensing in the 90 days prior to the last menstrual period and conception increased from 2 per 1,000 in 2020 to 15 per 1,000 in 2024, Brown explained
Some studies suggest that they help reduce the risk of heart and kidney disease, support liver health (especially in people with fatty liver disease), and may delay the progression of diabetic kidney complications
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