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Five clinical trials in type 2-diabetic subjects (SURPASS 15) have shown that tirzepatide at 515 mg per week reduces both HbA 1c (1.24 to 2.58%) and body weight (5.411.7 kg) by amounts unprecedented for a single agent

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This phenocopied the decrease in glucose-derived acetyl-CoA pools following knockdown of the de novo carnitine-synthesis enzyme TMLHE (Extended Data Fig