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Mechanistically, apelin enhances the PI3K/Akt pathway and transcription factor EB (TFEB)-mediated autophagy flux in NP cells (123, 124)

Researchers suggest Receptor Grade IGF-1 LR3 has the potential to induce a signaling mechanism in the organism, either via autocrine mode (where the tissue cell stimulates itself) or via paracrine mode (where the tissue cell stimulates the nearby cell)