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Kumar said the companys first priority is safety and transparency with patients about the risks and benefits of each drug
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Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide
References Hong Y, Downey T, Eu KW, Koh PK, Cheah PY
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