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Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells
The anabolic signal is real (IGF-1 receptor activation drives satellite cell proliferation and protein synthesis), but the cosmetic fullness in week one is predominantly glycogen and extracellular fluid, not contractile tissue
In conclusion, the complete history of GLP-1 drugs from gut hormone discovery to blockbuster therapy exemplifies the ideal arc of translational medicine
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