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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids
Animal gut anatomy and digestive physiology differ from humans, so caution is warranted in extrapolating these findings
doi: 10.1136/annrheumdis-2011-201605 34 LenertAFardoDW
In relation to the risk of developing cancer, a study published in The Journal of Clinical Endocrinology & Metabolism found no significant association between the dose of rhGH, mortality, and cancer incidence, making causality far less likely: Safety concerns have been raised regarding premature mortality, diabetes, neoplasia, and cerebrovascular disease in association with GH therapy
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