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It is approved by the United States Food and Drug Administration (FDA) for the treatment of excessive mucus secretions and for treatment of acetaminophen (Tylenol) overdose
Under replete conditions, GCLC ligates glutamate to cysteine in the first step of glutathione synthesis
Details of the reaction conditions, CpG sites assayed, and target site primers (Supplementary Table S3) are included in the supplementary methods
The liver uses glutathione to conjugate these toxins, making them water-soluble so they can be excreted
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