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Co-immunoprecipitation mass spectrometry and CRISPR KO in cells identified that mitochondrial m -AAA protease AFG3L2 is responsible for degrading SLC25A39 through the matrix loop 1
Typhoon FLA 9500 biomolecular imager (GE Healthcare) was used to detect fluorescence of these gels as described below
This is encouraging but limited - animal results do not always carry over to humans, and this is one study, not a body of evidence
When IgG auto-Abs bind to a cell-surface target, they can activate complement or immune cell-mediated inflammatory responses directed against non-pathogenic tissue [20, 131]
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