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However, intravenous administration of synthetic DSIP in 6 middle-aged human chronic insomniacs with disturbed sleep brought very good results, as longer sleep, higher quality with fewer interruptions and slightly more REM sleep

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This is likely also the case during systemic viral infections that result in severe oxidative stress (cell/tissue necrosis), a usual indication of late and failed attempts by the host to induce resistance (Hernndez et al., 2016