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Interestingly, some evidence suggests that reduced, but not absent, GPX4 activity may be associated with increased lifespan in mice, pointing to complex interactions between oxidative stress and ageing
Interestingly, DMF was found to induce cysteine biosynthesis 26 , elevate cellular GSH levels 27 , and present an NRF2-independent effect through posttranslational protein succinylation 28,29
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