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Quick conversions: 1.0 mg = 6 units , 1.5 mg = 9 units , and 2.0 mg = 12 units
There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
The pattern is also uniformly preclinical, and its original mechanistic core is retracted
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