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In an age-stratified meta-analysis of ELIXA, LEADER, SUSTAIN-6, EXSCEL, REWIND and PIONEER-6, the HR on MACE was 0.89 (95% CI 0.761.03) in those under 65 years of age and 0.86 (95% CI 0.800.92) in those aged 65 years or older ( p interaction = 0.73), 0.92 (95% CI 0.850.99) in those under 75 years and 0.75 (95% CI 0.610.92) in those 75 years or older ( p interaction = 0.07), indicating that the efficacy of GLP-1RA for MACE is consistent in older patients [8]
In contrast to water-soluble vitamins, your body has no easy way to get rid of fat-soluble vitamins
Start with the lowest 0.25 mg dose and increase only every four weeks minimum
Nutritional IV therapy typically doesn't interfere with immunosuppressive drugs or biologics
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