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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways
Obesity: pathophysiology and management
The choice between semaglutide and tirzepatide depends on individual metabolic factors and genetic predispositions
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