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Manganese peptide complexes (e.g., manganese tripeptide-1) have been explored as alternatives that avoid copper-related skin discoloration concerns while providing metal-dependent enzymatic activation
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41 Studies have found that individuals with lower CYP1A2 activity have increased reports of symptoms of toxicity, as caffeine is hepatically metabolized by CYP1A2 which causes caffeine to be absorbed more slowly
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