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The effects of the leptin-GLP-1 interaction may be governed by intracellular signaling pathways, including those involving phosphorylated STAT3 and PTP1B.15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass
171 SongP.XiaX.HanT.FangH.WangY.DongF.et al (2018)
Nitric oxide is a potent vasodilator and is the target of many drugs for erectile dysfunction in men
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