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Although this resembles the situation observed under inflammatory conditions, expression of Arx , Pax6 , Isl1 and Lmx1a was increased under inflammatory conditions in intestinal epithelial cells from IL-10 -/- mice ( Figure 2A,B )., arguing against Rfx6 as key driver of skewed differentiation
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This is significantly higher than the 2.4% to 3.1% average reduction seen with diet and exercise alone
Therefore, these cells could benefit from L-carnitine supplementation during an immune challenge
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