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Docking studies revealed that compounds with aromatic amine residues interact with the large pocket of DPP-4, while compounds with cyclic secondary amine residues bind in the small pocket, similar to Vildagliptin

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Potential primary treatment effect modifiers were identified from a previous ITC of GLP-1 RAs to be sex, glycated haemoglobin (HbA1c) and body weight [41]

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