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This study showed that a subgroup of patients using this innovative de-escalating approach omitting chemotherapy received a pCR response, and around one-third of the patients achieved a promising 3-yeat iDFS from surgery with chemotherapy-free therapy

It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]