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When a random set of parameters is generated, we then examined the generated set of initial parameters and whether they are confined to a steady state of metabolic flux for 24 hours before the glucose administration using the experimentally measured molecule concentrations as the initial values
To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines
This small protein is highly conserved amongst the actinomycetes and was given the name glycogen accumulation regulator (GarA) due to its observed effects on glycogen metabolism in Mycobacterium smegmatis [32], however it's precise function remained unclear at the time
