tirzepatide and oxycodone for Weight Loss Tirzepatide attenuates mesolimbic cocaine-evoked dopamine

Numbness and tingling are common Usually affects the thumb, index, and middle fingers Frequently worsens at night Shaking the hand may provide temporary relief May cause weak grip or hand clumsiness Caused by pressure on the median nerve Pain may occur without numbness or tingling Symptoms may be localized to a tendon or joint Often worsens mainly with movement or activity Finger pattern may not follow the median nerve Grip may hurt but remain neurologically intact May involve tendonitis, arthritis, injury, or another nerve Symptom patterns can overlap, so persistent numbness, weakness, or nighttime symptoms should be properly evaluated

Some people find Wegovys slower dose increase easier on their stomach, while others do fine with Zepbounds faster ramp-up

Surgeons recommend weight loss before surgery to get below the BMI cutoff, and to further reduce post-surgical risks

Long-acting, subcutaneously administered, PYY RA are undergoing early phase clinical trials as obesity treatments either alone or in combination with GLP-1 RA (Table 1, NCT02568306 and NCT03574584)