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The link between TPH2 and melatonin levels is indirect, but Ive included it here to illustrate the connection between melatonin precursors and disrupted circadian rhythm.[ref][ref] rs10830963 ( dbSNP) Research & references rs1387153 ( dbSNP) Research & references rs2375801 ( dbSNP) Research & references rs6553010 ( dbSNP) Research & references rs12506228 ( dbSNP) Research & references rs28936679 ( dbSNP) Research & references rs4290270 ( dbSNP) Research & references rs4570625 ( dbSNP) Research & references *Escitalopram is an antidepressant that acts on the circadian system.[ref] Methylation cycle: In the process of turning serotonin into melatonin, your body uses a methyl group