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A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating
Timing: Consistent timing (e.g., evenings)
Patients with certain genotypes may need lower starting doses to avoid early exhaustion
The colour was scaled across samples for each gene
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